Preventive action of proxazole in experimentally induced renal hypertension in rats.

Proxazole or 3-α-phenylpropyl-5-β-diethylaminoethyl-1, 2 4-oxadiazole citrate, is an unusual drug because it possesses both anti-inflammatory and antispasmodic proper ties (1) and because each of these two properties has some uncommon features. The anti inflammatory action takes place mostly against edematous responses and is devoid of ul cerogenic effects which are instead produced by most anti-inflammatory drugs; moreover proxazole prevents indomethacin-induced ulcers without exerting any anti-secretory effect (2-3). The antispasmodic activity results in a specific inhibition of smooth muscle spasm, both at the vascular and at the intestinal level, without significant interferences with the